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Compared with mouse thymocytes, mouse ES cells include higher ranges of whole genomic H3K4me3 and have increased H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 46 In settlement with this, world decreases in H3K4me3 ranges happen during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic changes in H3K4me3 profiles at specific units of genes during ES cell differentiation.
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